University of Pittsburgh
Synthetic
Morphogenesis
We take a synthetic approach to tissue formation, pushing human brain and cardiac organoids to new states. Combining quantitative imaging, computational analysis, and molecular profiling, we discover novel regulatory genes and the general physical principles governing how form emerges from cells.
Research Themes
We take a synthetic approach to engineer new living materials, combining organoid biology with physics and computation to understand and design how tissues acquire form and function.
Cardiac Organoids
Engineering human cardiac organoids and pairing them with AI and quantitative assays for discovery and drug screening.
Brain Organoids
Neuroepithelial morphogenesis, 3D imaging, and quantitative morphology.
Computational Methods
Image analysis pipelines and biophysical modeling tools for quantitative biology.
Biological Physics
Osmotic biophysics and tissue mechanics governing how cells sense and organize.