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Publications

2026

Senescence targeting re-enables injury-responsive repair in a human RPE aging model

Ritschka B, Etl C, Becerril Perez F, Ishihara K, Almedawar S, Leyva Gonzalez M, Neubauer H, Bakker RA, Tanaka EM

bioRxiv · 2026DOI ↗
Minimal essential requirements for neural tube self-organisation

Stuart HT, Costantini E, Wang J, Krammer T, Delas MJ, Melchionda M, Cornwall-Scoones J, Schmauss G, Lendl T, Ishihara K, Rand D, Sáez M, Tanaka EM, Briscoe J

bioRxiv · 2026DOI ↗
ATAC-seq of low-input and cryopreserved primordial germ cells reveals functional enhancers

Kawaguchi A, Igari M, Murayama Y, Iikawa H, Sakamoto M, Nakamura Y, Kuraku S, Ishihara K, Saito D

Development · 2026DOI ↗
Synthetic lumen rounding directs neural progenitor division mode

Marchenko M, Martínez Ara G, Pulikkal J, Ishihara K, Ebisuya M

bioRxiv · 2026DOI ↗
Hyaluronan underlies the emergence of form, fate, and function in human cardioids

Jahnel SM, Dimitriadi A, Kodnar J, Gerakopoulos V, Khurana Y, Mayrhauser M, Ilmer T, Aguech MA, Hall AR, Ishihara K*, Mendjan S*

bioRxiv · 2026DOI ↗* Corresponding authors

2024

Mouse neural tube organoids self-organize floorplate through BMP-mediated cluster competition

Krammer T, Stuart HT, Gromberg E, Ishihara K, Cislo D, Melchionda M, Becerril Perez F, Wang J, Costantini E, Lehr S, Arbanas L, Hörmann A, Neumuller RA, Elvassore N, Siggia E, Briscoe J, Kicheva A, Tanaka EM

Developmental Cell · 2024DOI ↗
The endoplasmic reticulum connects to the nucleus by constricted junctions that mature after mitosis

Bragulat-Teixidor H, Ishihara K, Szücs GM, Otsuka S

EMBO Reports · 2024DOI ↗

2023

Topological morphogenesis of neuroepithelial organoids

Ishihara K, Mukherjee A, Gromberg E, Brugués J, Tanaka EM, Jülicher F

Nature Physics · 2023DOI ↗

2016–2021

Force generation by protein–DNA co-condensation

Quail T, Golfier S, Elsner M, Ishihara K, Murugesan V, Renger R, Jülicher F, Brugués J

Nature Physics · 2021DOI ↗
Spatial variation of microtubule depolymerization in large asters suggests regulation by MAP depletion

Ishihara K, Decker F, Caldas P, Pelletier JF, Loose M, Brugués J, Mitchison TJ

Molecular Biology of the Cell · 2021DOI ↗
Spindle scaling is governed by cell boundary regulation of microtubule nucleation

Rieckhoff EM, Berndt F, Elsner M, Golfier S, Decker F, Ishihara K, Brugués J

Current Biology · 2020DOI ↗
Traveling fronts in self-replicating persistent random walks with multiple internal states

Ishihara K, George AB, Cornelius R, Korolev KS

New Journal of Physics · 2020DOI ↗
How to tune spindle size relative to cell size?

Rieckhoff EM, Ishihara K, Brugués J

Current Opinion in Cell Biology · 2019DOI ↗
Spontaneous symmetry breaking and pattern formation of organoids

Ishihara K, Tanaka EM

Current Opinion in Systems Biology · 2018DOI ↗
Reconstitution of a patterned neural tube from single mouse embryonic stem cells

Ishihara K, Ranga A, Lutolf MP, Tanaka EM, Meinhardt A

Methods in Molecular Biology · 2017DOI ↗
Physical basis of large microtubule aster growth

Ishihara K, Korolev KS, Mitchison TJ

eLife · 2016DOI ↗

Before 2016

The nuclear proteome of a vertebrate

Wühr M, Güttler T, Peshkin L, McAlister GC, Sonnett M, Ishihara K, Groen AC, Presler M, Erickson BK, Mitchison TJ, Kirschner MW, Gygi SP

Current Biology · 2015DOI ↗
Size scaling of microtubule assemblies in early Xenopus embryos

Mitchison TJ, Ishihara K, Nguyen P, Wühr M

Cold Spring Harbor Perspectives in Biology · 2015DOI ↗
Microtubule nucleation remote from centrosomes may explain how asters span large cells

Ishihara K, Nguyen PA, Groen AC, Field CM, Mitchison TJ

Proceedings of the National Academy of Sciences · 2014DOI ↗
Spatial organization of cytokinesis signaling reconstituted in a cell-free system

Nguyen PA, Groen AC, Loose M, Ishihara K, Wühr M, Field CM, Mitchison TJ

Science · 2014DOI ↗
Organization of early frog embryos by chemical waves emanating from centrosomes

Ishihara K, Nguyen PA, Wühr M, Groen AC, Field CM, Mitchison TJ

Philosophical Transactions of the Royal Society B · 2014DOI ↗
Glycogen-Supplemented Mitotic Cytosol for Analyzing Xenopus Egg Microtubule Organization

Groen AC, Nguyen PA, Field CM, Ishihara K, Mitchison TJ

Methods in Enzymology · 2014DOI ↗
Xenopus Egg Cytoplasm with Intact Actin

Field CM, Nguyen PA, Ishihara K, Groen AC, Mitchison TJ

Methods in Enzymology · 2014DOI ↗
Branching microtubule nucleation in Xenopus egg extracts mediated by Augmin and TPX2

Petry S, Groen AC, Ishihara K, Mitchison TJ, Vale RD

Cell · 2013DOI ↗
Context-dependent transcriptional interpretation of mitogen activated protein kinase signaling in the Drosophila embryo

Kim Y, Iagovitina A, Ishihara K, Fitzgerald KM, Deplancke B, Papatsenko D, Shvartsman SY

Chaos: An Interdisciplinary Journal of Nonlinear Science · 2013DOI ↗
Growth, interaction, and positioning of microtubule asters in extremely large vertebrate embryo cells

Mitchison T, Wühr M, Nguyen P, Ishihara K, Groen A, Field CM

Cytoskeleton · 2012DOI ↗
Pronuclear Migration: No Attachment? No Union, but a Futile Cycle!

Nguyen PA, Ishihara K, Wühr M, Mitchison TJ

Current Biology · 2012DOI ↗